The TLR7 agonist imiquimod selectively inhibits IL-4-induced IgE production by suppressing IgG1/IgE class switching and germline ε transcription through the induction of BCL6 expression in B cells. [electronic resource]
Producer: 20200226Description: 1-8 p. digitalISSN:- 1090-2163
- Animals
- Antibody Formation
- B-Lymphocytes -- physiology
- CD40 Antigens -- metabolism
- Cells, Cultured
- Gene Expression Regulation
- Imiquimod -- pharmacology
- Immunoglobulin Class Switching
- Immunoglobulin E -- genetics
- Immunoglobulin G -- genetics
- Immunoglobulin epsilon-Chains -- genetics
- Interleukin-4 -- metabolism
- Mice
- Mice, Inbred C57BL
- Proto-Oncogene Proteins c-bcl-6 -- genetics
- RNA, Small Interfering -- genetics
- Toll-Like Receptor 7 -- agonists
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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