Design, synthesis and biological study of hybrid drug candidates of nitric oxide releasing cucurbitacin-inspired estrone analogs for treatment of hepatocellular carcinoma. [electronic resource]
Producer: 20200131Description: 515-533 p. digitalISSN:- 1090-2120
- Antineoplastic Agents -- chemical synthesis
- Carcinoma, Hepatocellular -- drug therapy
- Cucurbitacins -- chemical synthesis
- Drug Design
- Drug Screening Assays, Antitumor
- Estrone -- analogs & derivatives
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Hep G2 Cells
- Humans
- Liver Neoplasms -- drug therapy
- MAP Kinase Signaling System -- drug effects
- Molecular Docking Simulation
- Molecular Structure
- Multidrug Resistance-Associated Protein 2
- Multidrug Resistance-Associated Proteins -- antagonists & inhibitors
- Nitric Oxide -- metabolism
- Nitric Oxide Donors -- chemical synthesis
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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