Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. [electronic resource]
Producer: 20190624Description: 885-899.e6 p. digitalISSN:- 1097-4164
- Ataxia Telangiectasia Mutated Proteins -- genetics
- BRCA1 Protein -- genetics
- BRCA2 Protein -- genetics
- CRISPR-Cas Systems
- Cell Death
- Cell Line, Tumor
- DNA Damage
- DNA End-Joining Repair
- DNA-(Apurinic or Apyrimidinic Site) Lyase -- genetics
- Endonucleases
- Flap Endonucleases -- genetics
- Gene Expression Regulation, Neoplastic
- Genes, Lethal
- Humans
- Multifunctional Enzymes
- Neoplasms -- drug therapy
- Poly(ADP-ribose) Polymerase Inhibitors -- pharmacology
- Proliferating Cell Nuclear Antigen -- genetics
- Protein Binding
- Protein Interaction Domains and Motifs
- RNA Interference
- RNA, Small Interfering -- genetics
- Synthetic Lethal Mutations
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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