Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. [electronic resource]
Producer: 20190219Description: 244 p. digitalISSN:- 2041-1723
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Benzimidazoles -- pharmacology
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- genetics
- Drug Screening Assays, Antitumor
- Epigenesis, Genetic -- drug effects
- Female
- GTP Phosphohydrolases -- genetics
- HEK293 Cells
- Humans
- Inhibitory Concentration 50
- Isocitrate Dehydrogenase -- genetics
- Leukemia, Myeloid, Acute -- drug therapy
- Male
- Membrane Proteins -- genetics
- Mice
- Middle Aged
- Mutation -- drug effects
- Piperidines -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Pyridones -- pharmacology
- Pyrimidinones -- pharmacology
- Tandem Repeat Sequences -- genetics
- Treatment Outcome
- Exome Sequencing
- fms-Like Tyrosine Kinase 3 -- genetics
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Publication Type: Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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