Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progression. [electronic resource]
Producer: 20190625Description: 263-275 p. digitalISSN:- 2352-3964
- Animals
- Apoptosis -- drug effects
- Autoantigens -- genetics
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cisplatin -- pharmacology
- DNA-Binding Proteins
- Disease Models, Animal
- Erlotinib Hydrochloride -- pharmacology
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Histone Chaperones -- metabolism
- Humans
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins -- genetics
- Mice
- Models, Biological
- Promoter Regions, Genetic
- Protein Kinase Inhibitors -- pharmacology
- Protein Phosphatase 2 -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Signal Transduction -- drug effects
- Transcription Factors -- metabolism
- Triple Negative Breast Neoplasms -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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