Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold. [electronic resource]
Producer: 20200203Description: 229-239 p. digitalISSN:- 1090-2120
- Animals
- Antitubercular Agents -- chemical synthesis
- Bacterial Proteins -- antagonists & inhibitors
- Catalytic Domain
- Cell Line
- Drug Evaluation, Preclinical
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Mice
- Microsomes, Liver -- metabolism
- Molecular Docking Simulation
- Molecular Structure
- Mycobacterium tuberculosis -- drug effects
- Protein Binding
- Protein Tyrosine Phosphatases -- antagonists & inhibitors
- Structure-Activity Relationship
- Thiobarbiturates -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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