Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors. [electronic resource]
Producer: 20191210Description: 502-515 p. digitalISSN:- 1464-3391
- Animals
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Benzimidazoles -- chemical synthesis
- Cell Cycle Checkpoints -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- HEK293 Cells
- Hepatocytes -- drug effects
- Humans
- Mice
- Molecular Docking Simulation
- Molecular Structure
- Polymerization -- drug effects
- Pyrazoles -- chemistry
- Structure-Activity Relationship
- Sulfonamides -- chemistry
- Tubulin -- metabolism
- Tubulin Modulators -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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