Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody. [electronic resource]
Producer: 20190528Description: e0209509 p. digitalISSN:- 1932-6203
- Animals
- Antibodies, Monoclonal -- genetics
- Antibody Affinity
- Complement Activation -- drug effects
- Complement C5 -- antagonists & inhibitors
- Computer Simulation
- Drug Discovery -- methods
- Endosomes -- immunology
- Histocompatibility Antigens Class I -- genetics
- Humans
- Hydrogen-Ion Concentration
- Immune System Diseases -- drug therapy
- Macaca fascicularis
- Mice
- Mice, Transgenic
- Mutagenesis
- Protein Engineering -- methods
- Receptors, Fc -- genetics
- Recombinant Proteins -- immunology
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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