Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential. [electronic resource]
Producer: 20200312Description: 365-380 p. digitalISSN:- 1096-0929
- Action Potentials -- drug effects
- Animals
- Anti-Arrhythmia Agents -- toxicity
- Drug Evaluation, Preclinical
- ERG1 Potassium Channel -- metabolism
- Female
- Heart Ventricles -- drug effects
- Humans
- Ion Channels -- metabolism
- Male
- Myocytes, Cardiac -- drug effects
- Patch-Clamp Techniques
- Phenethylamines -- toxicity
- Potassium Channel Blockers -- toxicity
- Rabbits
- Sotalol -- toxicity
- Sulfonamides -- toxicity
- Terfenadine -- toxicity
- Tissue Donors
- Verapamil -- toxicity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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