Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines. [electronic resource]
Producer: 20190618Description: 57-67 p. digitalISSN:- 1096-7184
- Animals
- Antimetabolites -- pharmacology
- Bone Morphogenetic Protein 4 -- biosynthesis
- Bone Morphogenetic Protein Receptors -- antagonists & inhibitors
- CHO Cells
- CRISPR-Cas Systems
- Cricetinae
- Cricetulus
- Feedback, Physiological
- Gene Expression Profiling
- Gene Knockout Techniques
- Homeostasis
- Methotrexate -- pharmacology
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- Recombinant Proteins
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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