Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. [electronic resource]
Producer: 20181219Description: 4795 p. digitalISSN:- 2041-1723
- Aortic Dissection -- genetics
- Animals
- Antihypertensive Agents -- pharmacology
- Aorta -- drug effects
- Aortic Rupture -- genetics
- Calcium-Binding Proteins
- Disease Models, Animal
- Endothelial Cells -- drug effects
- Gene Deletion
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Glycogen Synthase Kinase 3 beta -- antagonists & inhibitors
- Hematoma -- genetics
- Humans
- Hypertension -- drug therapy
- Intracellular Signaling Peptides and Proteins -- deficiency
- Male
- Mice
- Mice, Knockout
- Muscle Proteins -- deficiency
- Myocytes, Smooth Muscle -- drug effects
- Primary Cell Culture
- Protein Isoforms -- deficiency
- Protein Kinase Inhibitors -- pharmacology
- rho-Associated Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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