Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo. [electronic resource]
Producer: 20191104Description: 126-136 p. digitalISSN:- 1872-7980
- Animals
- Antineoplastic Agents -- chemistry
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Binding Sites
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Esophageal Neoplasms -- drug therapy
- Esophageal Squamous Cell Carcinoma -- drug therapy
- Female
- Flavonoids -- chemistry
- G2 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- MAP Kinase Kinase 3 -- antagonists & inhibitors
- MAP Kinase Kinase 6 -- antagonists & inhibitors
- Mice, SCID
- Molecular Docking Simulation
- Protein Conformation
- Protein Kinase Inhibitors -- chemistry
- Signal Transduction -- drug effects
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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