Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in [electronic resource]
Producer: 20191223Description: 1598-1613 p. digitalISSN:- 2159-8290
- A549 Cells
- Aniline Compounds -- administration & dosage
- Animals
- Antineoplastic Agents -- administration & dosage
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Benzamides -- pharmacology
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cell Line, Tumor
- Diphenylamine -- analogs & derivatives
- Humans
- Lung Neoplasms -- drug therapy
- Mice, Knockout
- Mice, Nude
- Mice, SCID
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Myeloid Cell Leukemia Sequence 1 Protein -- antagonists & inhibitors
- Protein Kinase Inhibitors -- administration & dosage
- Proto-Oncogene Proteins p21(ras) -- antagonists & inhibitors
- Sulfonamides -- administration & dosage
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays -- methods
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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