Inhibition of MYC attenuates tumor cell self-renewal and promotes senescence in SMARCB1-deficient Group 2 atypical teratoid rhabdoid tumors to suppress tumor growth in vivo. [electronic resource]
Producer: 20190709Description: 1983-1995 p. digitalISSN:- 1097-0215
- Animals
- Azepines -- pharmacology
- Bone Morphogenetic Proteins -- genetics
- Cell Line, Tumor
- Cell Self Renewal -- drug effects
- Cell Transformation, Neoplastic -- genetics
- Cellular Senescence -- drug effects
- Chromatin -- genetics
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Mice
- Mice, Nude
- Proto-Oncogene Proteins c-myc -- genetics
- Rhabdoid Tumor -- genetics
- SMARCB1 Protein -- genetics
- Teratoma -- genetics
- Triazoles -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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