Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival. [electronic resource]
Producer: 20191111Description: 13759 p. digitalISSN:- 2045-2322
- Antigens, Neoplasm -- genetics
- Carbonic Anhydrase IX -- antagonists & inhibitors
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival
- DNA-(Apurinic or Apyrimidinic Site) Lyase -- antagonists & inhibitors
- Gene Expression Regulation, Neoplastic -- genetics
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- genetics
- Pancreatic Neoplasms -- drug therapy
- Signal Transduction -- drug effects
- Small Molecule Libraries -- pharmacology
- Transcription, Genetic -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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