TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. [electronic resource]
Producer: 20181212Description: 2731 p. digitalISSN:- 2041-1723
- Adenocarcinoma of Lung -- drug therapy
- Animals
- Antineoplastic Agents -- pharmacology
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors -- genetics
- Calcium -- metabolism
- Cathepsins -- antagonists & inhibitors
- Cell Line, Tumor
- Cysteine Proteinase Inhibitors -- pharmacology
- Exocytosis
- Gene Expression Regulation, Neoplastic
- Humans
- Leucine -- analogs & derivatives
- Lung Neoplasms -- drug therapy
- Lysosomes -- drug effects
- Membrane Proteins -- genetics
- Mice
- Neoplasm Metastasis
- Nerve Tissue Proteins -- genetics
- Prognosis
- Protein Isoforms -- genetics
- Proteolysis
- Signal Transduction
- Survival Analysis
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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