Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway. [electronic resource]
Producer: 20191011ISSN:- 1937-9145
- Active Transport, Cell Nucleus
- Adult
- Aged, 80 and over
- Case-Control Studies
- Cell Nucleus -- metabolism
- Cells, Cultured
- Cellular Senescence
- Child
- Female
- Fibroblasts -- metabolism
- Humans
- Male
- Microtubules -- metabolism
- N-Terminal Acetyltransferase E -- antagonists & inhibitors
- N-Terminal Acetyltransferases
- Nuclear Pore Complex Proteins -- genetics
- Phenotype
- Progeria -- genetics
- Proto-Oncogene Proteins -- genetics
- Young Adult
- beta Karyopherins -- genetics
- ran GTP-Binding Protein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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