A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells. [electronic resource]
Producer: 20190506Description: 1892-1908 p. digitalISSN:- 1535-9484
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Colorectal Neoplasms -- genetics
- Down-Regulation -- drug effects
- Drug Synergism
- ErbB Receptors -- antagonists & inhibitors
- Feedback, Physiological
- Gene Expression Regulation, Neoplastic -- drug effects
- Gene Knockout Techniques
- Humans
- MAP Kinase Signaling System -- drug effects
- Models, Biological
- Mutation -- genetics
- Phosphatidylinositol 3-Kinases -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 -- metabolism
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt -- metabolism
- Systems Biology -- methods
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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