Mevalonate pathway blockage enhances the efficacy of mTOR inhibitors with the activation of retinoblastoma protein in renal cell carcinoma. [electronic resource]
Producer: 20190909Description: 182-189 p. digitalISSN:- 1872-7980
- Animals
- Apoptosis
- Carcinoma, Renal Cell -- drug therapy
- Cell Line, Tumor
- Cell Survival
- Enzyme Inhibitors -- therapeutic use
- Everolimus -- therapeutic use
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- therapeutic use
- Kidney Neoplasms -- drug therapy
- Mevalonic Acid -- metabolism
- Mice
- Mice, SCID
- Prenylation
- Progression-Free Survival
- RNA, Small Interfering -- metabolism
- Retinoblastoma Binding Proteins -- genetics
- Retrospective Studies
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Treatment Outcome
- Ubiquitin-Protein Ligases -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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