Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish. [electronic resource]
Producer: 20181231Description: 32-42 p. digitalISSN:- 1096-0333
- Animals
- Animals, Genetically Modified
- Antigens, CD -- metabolism
- Atorvastatin -- toxicity
- Cadherins -- metabolism
- Cell Survival -- drug effects
- Cerebral Hemorrhage -- chemically induced
- Dose-Response Relationship, Drug
- Endothelium, Vascular -- drug effects
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Phenanthrenes -- pharmacology
- Zebrafish
- rho-Associated Kinases -- metabolism
- rhoA GTP-Binding Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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