Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. [electronic resource]
Producer: 20180801Description: e0196352 p. digitalISSN:- 1932-6203
- Adolescent
- Adult
- Aging -- blood
- Anti-Inflammatory Agents -- pharmacology
- Azithromycin -- pharmacology
- Caspase 1 -- metabolism
- Cytokines -- biosynthesis
- Dexamethasone -- pharmacology
- Drug Synergism
- Dual Specificity Phosphatase 1 -- genetics
- Enzyme Activation -- drug effects
- Female
- Gene Expression Regulation -- drug effects
- Humans
- Infant, Newborn
- Inflammasomes -- metabolism
- Middle Aged
- Mitogen-Activated Protein Kinases -- metabolism
- Monocytes -- drug effects
- NF-kappa B -- metabolism
- Pentoxifylline -- pharmacology
- Pregnancy
- RNA, Messenger -- genetics
- Signal Transduction -- drug effects
- Toll-Like Receptors -- metabolism
- Young Adult
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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