APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells. [electronic resource]
Producer: 20190625Description: 1177-1186 p. digitalISSN:- 1538-8514
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Cycle Checkpoints -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- DNA Damage -- drug effects
- Dose-Response Relationship, Drug
- G-Quadruplexes -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Imidazoles -- pharmacology
- Leukemia, Myeloid, Acute -- genetics
- Phenanthrolines -- pharmacology
- Proto-Oncogene Proteins c-myc -- chemistry
- Signal Transduction -- drug effects
- Stress, Physiological -- drug effects
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Publication Type: Journal Article
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