Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic Insights. [electronic resource]
Producer: 20190624Description: 1791-1797 p. digitalISSN:- 1520-6017
- Albumins -- metabolism
- Anilino Naphthalenesulfonates -- pharmacokinetics
- Animals
- Biological Transport
- Fluorescent Dyes -- pharmacokinetics
- Hepatocytes -- metabolism
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacokinetics
- Kinetics
- Liver -- metabolism
- Metabolic Clearance Rate
- Models, Biological
- Protein Binding
- Quinolines -- pharmacokinetics
- Rats
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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