Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells. [electronic resource]
Producer: 20180427Description: 54-62 p. digitalISSN:- 1879-3169
- Active Transport, Cell Nucleus -- drug effects
- Basic Helix-Loop-Helix Transcription Factors -- agonists
- Benzo(a)pyrene -- toxicity
- Bronchi -- drug effects
- Carcinogens, Environmental -- toxicity
- Cell Line
- Cell Survival -- drug effects
- Cytochrome P-450 CYP1A1 -- chemistry
- DNA Adducts -- chemistry
- Enzyme Activation -- drug effects
- Enzyme Induction -- drug effects
- Humans
- Hydrophobic and Hydrophilic Interactions
- Kinetics
- MAP Kinase Signaling System -- drug effects
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Protein Processing, Post-Translational -- drug effects
- Proto-Oncogene Proteins pp60(c-src) -- chemistry
- Receptors, Aryl Hydrocarbon -- agonists
- Respiratory Mucosa -- drug effects
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Publication Type: Journal Article
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