Discovery of Novel KRAS-PDEδ Inhibitors by Fragment-Based Drug Design. [electronic resource]
Producer: 20190417Description: 2604-2610 p. digitalISSN:- 1520-4804
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Cell Line
- Cyclic Nucleotide Phosphodiesterases, Type 6 -- antagonists & inhibitors
- Drug Design
- Drug Discovery
- Humans
- MAP Kinase Signaling System -- drug effects
- Oncogene Protein v-akt -- drug effects
- Peptide Fragments -- chemistry
- Protein Binding
- Proto-Oncogene Proteins p21(ras) -- chemical synthesis
- Reactive Oxygen Species -- metabolism
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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