Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3. [electronic resource]
Producer: 20190607Description: 12 p. digitalISSN:- 1755-8794
- Apoptosis
- Cell Proliferation
- Drug Resistance, Neoplasm
- Humans
- Imidazoles -- pharmacology
- Lung Neoplasms -- drug therapy
- Phosphatidylinositol 3-Kinases -- genetics
- Piperazines -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Signal Transduction
- TOR Serine-Threonine Kinases -- genetics
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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