Sabutoclax, pan-active BCL-2 protein family antagonist, overcomes drug resistance and eliminates cancer stem cells in breast cancer. [electronic resource]
Producer: 20190617Description: 47-59 p. digitalISSN:- 1872-7980
- Animals
- Breast Neoplasms -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Doxorubicin -- administration & dosage
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Gossypol -- administration & dosage
- Humans
- Interleukin-6 -- metabolism
- MCF-7 Cells
- Mice
- Neoplastic Stem Cells -- drug effects
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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