Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD. [electronic resource]
Producer: 20190916Description: 1165-1181 p. digitalISSN:- 1533-3450
- Animals
- Bone Marrow Transplantation
- Caspase 1 -- metabolism
- DNA -- metabolism
- DNA-Binding Proteins -- deficiency
- Diabetic Nephropathies -- metabolism
- Enzyme Activation
- Fibrosis
- Humans
- Inflammasomes -- physiology
- Interleukin-1beta -- metabolism
- Kidney Glomerulus -- metabolism
- Kidney Tubules -- metabolism
- Leukocytes -- metabolism
- Macrophages -- physiology
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Necrosis
- Nephrosclerosis -- metabolism
- Phagocytosis
- Phenotype
- Radiation Chimera
- Renal Insufficiency, Chronic -- metabolism
- THP-1 Cells
- Ureteral Obstruction -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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