Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins. [electronic resource]
Producer: 20190827Description: 846-857 p. digitalISSN:- 1755-3245
- Animals
- Animals, Newborn
- Biomechanical Phenomena
- Cardiomyopathies -- genetics
- Cells, Cultured
- Elastic Modulus
- Fluorescent Antibody Technique
- Genetic Predisposition to Disease
- Humans
- Lamin Type A -- chemistry
- Microscopy, Atomic Force
- Molecular Dynamics Simulation
- Mutation
- Myocardial Contraction
- Myocytes, Cardiac -- drug effects
- Phenotype
- Protein Conformation, alpha-Helical
- Protein Kinase Inhibitors -- pharmacology
- Rats
- Structure-Activity Relationship
- p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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