The CDK inhibitor purvalanol A induces neutrophil apoptosis and increases the turnover rate of Mcl-1: potential role of p38-MAPK in regulation of Mcl-1 turnover. [electronic resource]
Producer: 20190418Description: 171-180 p. digitalISSN:- 1365-2249
- Apoptosis -- drug effects
- Cells, Cultured
- Gene Expression Regulation
- Granulocyte-Macrophage Colony-Stimulating Factor -- metabolism
- Healthy Volunteers
- Humans
- Monocytes -- drug effects
- Myeloid Cell Leukemia Sequence 1 Protein -- genetics
- Naphthalenes -- pharmacology
- Neutrophils -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- Purines -- pharmacology
- Pyrazoles -- pharmacology
- Signal Transduction -- drug effects
- p38 Mitogen-Activated Protein Kinases -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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