Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. [electronic resource]
Producer: 20190403Description: 1601-1605 p. digitalISSN:- 1521-3773
- Antineoplastic Agents -- chemistry
- Binding Sites
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Crystallography, X-Ray
- Drug Design
- Histone-Lysine N-Methyltransferase -- antagonists & inhibitors
- Humans
- Molecular Dynamics Simulation
- Myeloid-Lymphoid Leukemia Protein -- antagonists & inhibitors
- Protein Interaction Domains and Motifs -- drug effects
- Protein Structure, Tertiary
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Small Molecule Libraries -- chemistry
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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