Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells. [electronic resource]
Producer: 20190219Description: 1016-1022 p. digitalISSN:- 1476-5551
- Adult
- Aged
- Aged, 80 and over
- Animals
- Apoptosis -- drug effects
- Cell Cycle Checkpoints -- drug effects
- Cell Line, Tumor
- Dasatinib -- pharmacology
- Dogs
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Female
- G2 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Leukemia, Mast-Cell -- drug therapy
- Male
- Mast Cells -- drug effects
- Mastocytosis, Systemic -- drug therapy
- Middle Aged
- Norbornanes -- pharmacology
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-kit -- metabolism
- Pyrimidines -- pharmacology
- STAT5 Transcription Factor -- metabolism
- Staurosporine -- analogs & derivatives
- Tumor Suppressor Proteins -- metabolism
- Young Adult
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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