Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. [electronic resource]
Producer: 20181126Description: 72-84.e7 p. digitalISSN:- 1878-4186
- Amino Acid Sequence
- Amino Acid Substitution
- Catalytic Domain
- Cloning, Molecular
- Crystallography, X-Ray
- Enzyme Activation
- Enzyme Inhibitors -- chemical synthesis
- Escherichia coli -- genetics
- Gene Expression
- Genetic Vectors -- chemistry
- Humans
- Hydrophobic and Hydrophilic Interactions
- Kinetics
- Molecular Dynamics Simulation
- Mutation
- Peptidomimetics -- chemical synthesis
- Protein Binding
- Protein Conformation, alpha-Helical
- Protein Conformation, beta-Strand
- Protein Interaction Domains and Motifs
- Recombinant Proteins -- chemistry
- Static Electricity
- Substrate Specificity
- Thermodynamics
- Ubiquitin-Specific Peptidase 7 -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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