Synergistic Targeting of the Regulatory and Catalytic Subunits of PI3Kδ in Mature B-cell Malignancies. [electronic resource]
Producer: 20190911Description: 1103-1113 p. digitalISSN:- 1557-3265
- Aminopyridines -- pharmacology
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- B-Lymphocytes -- metabolism
- Benzamides -- pharmacology
- Catalytic Domain -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Class I Phosphatidylinositol 3-Kinases -- antagonists & inhibitors
- Cyclic Nucleotide Phosphodiesterases, Type 4 -- genetics
- Cyclopropanes -- pharmacology
- Drug Repositioning
- Drug Synergism
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
- Lymphoma, Large B-Cell, Diffuse -- drug therapy
- Mice
- Mice, Nude
- Phosphodiesterase 4 Inhibitors -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Purines -- pharmacology
- Quinazolinones -- pharmacology
- Receptors, Antigen, B-Cell -- metabolism
- Signal Transduction -- drug effects
- Syk Kinase -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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