Discovery and characterization of highly potent and selective allosteric USP7 inhibitors. [electronic resource]
Producer: 20190503Description: 118-125 p. digitalISSN:- 1552-4469
- Allosteric Site
- Antineoplastic Agents -- chemistry
- Binding Sites
- Cell Line, Tumor
- Crystallography, X-Ray
- Drug Design
- Drug Discovery
- Drug Screening Assays, Antitumor
- Humans
- Inhibitory Concentration 50
- Kinetics
- Oxidation-Reduction
- Protease Inhibitors -- chemistry
- Protein Binding
- Protein Conformation
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Substrate Specificity
- Tumor Suppressor Protein p53 -- chemistry
- Ubiquitin-Specific Peptidase 7 -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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