The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD. [electronic resource]
Producer: 20180907Description: 1529 p. digitalISSN:- 2041-1723
- Aminohydrolases -- metabolism
- Anti-Bacterial Agents -- pharmacology
- Antineoplastic Agents -- pharmacology
- Bacterial Proteins -- metabolism
- Biofilms -- drug effects
- Biological Products -- pharmacology
- Cell Line, Tumor
- Crystallography, X-Ray
- Enzyme Assays
- Folic Acid -- metabolism
- Formate-Tetrahydrofolate Ligase -- metabolism
- Humans
- Inhibitory Concentration 50
- Macrolides -- pharmacology
- Methylenetetrahydrofolate Dehydrogenase (NADP) -- metabolism
- Microbial Sensitivity Tests
- Minor Histocompatibility Antigens -- metabolism
- Mitochondria -- metabolism
- Multienzyme Complexes -- metabolism
- Multifunctional Enzymes -- metabolism
- Myxococcales -- metabolism
- Neoplasms -- drug therapy
- Protein Binding
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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