Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn. [electronic resource]
Producer: 20190321Description: 224-238 p. digitalISSN:- 1872-6623
- Anilides -- pharmacology
- Animals
- Central Nervous System Sensitization -- drug effects
- Disease Models, Animal
- Female
- Fingolimod Hydrochloride -- therapeutic use
- Immunosuppressive Agents -- therapeutic use
- Male
- Mice
- Mice, Inbred C57BL
- Motor Activity -- drug effects
- Multiple Sclerosis -- chemically induced
- Myelin-Oligodendrocyte Glycoprotein -- toxicity
- Neuralgia -- drug therapy
- Organophosphonates -- pharmacology
- Oxadiazoles -- pharmacology
- Pain Threshold -- drug effects
- Peptide Fragments -- toxicity
- Receptors, Lysosphingolipid -- metabolism
- Sphingosine-1-Phosphate Receptors
- Spinal Cord -- metabolism
- Spinal Nerve Roots -- drug effects
- Subcellular Fractions -- drug effects
- Thiophenes -- pharmacology
- eIF-2 Kinase -- metabolism
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Publication Type: Journal Article
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