Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers. [electronic resource]
Producer: 20180907Description: 1476 p. digitalISSN:- 2041-1723
- Biflavonoids -- pharmacology
- Cell-Free System
- Computational Biology
- Epoxy Compounds -- pharmacology
- Exons -- genetics
- Fibroblasts
- HEK293 Cells
- HeLa Cells
- Humans
- Ligands
- Macrolides -- pharmacology
- Muscular Atrophy, Spinal -- drug therapy
- Piperazines -- chemical synthesis
- Protein Binding
- Protein Structure, Quaternary
- Proteomics -- methods
- RNA Precursors -- genetics
- RNA Splicing -- drug effects
- RNA, Messenger -- genetics
- RNA-Binding Proteins -- metabolism
- Spliceosomes -- drug effects
- Survival of Motor Neuron 1 Protein -- genetics
- Survival of Motor Neuron 2 Protein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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