Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding. [electronic resource]
Producer: 20181114Description: 69-88 p. digitalISSN:- 1083-351X
- Amino Acid Sequence
- Animals
- Diabetes Mellitus, Experimental -- drug therapy
- Humans
- Hypoglycemic Agents -- chemistry
- Insulin -- analogs & derivatives
- Models, Molecular
- Nuclear Magnetic Resonance, Biomolecular
- Protein Binding
- Protein Conformation
- Protein Denaturation
- Protein Engineering
- Protein Stability
- Rats
- Receptor, Insulin -- metabolism
- Swine
- Thermodynamics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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