Metoprolol prevents chronic obstructive sleep apnea-induced atrial fibrillation by inhibiting structural, sympathetic nervous and metabolic remodeling of the atria. [electronic resource]
Producer: 20190715Description: 14941 p. digitalISSN:- 2045-2322
- AMP-Activated Protein Kinase Kinases
- Adrenergic beta-1 Receptor Antagonists -- pharmacology
- Animals
- Atrial Fibrillation -- etiology
- Atrial Remodeling -- drug effects
- Cell Line
- Chronic Disease
- Disease Models, Animal
- Dogs
- Heart Atria -- drug effects
- Humans
- Male
- Metoprolol -- pharmacology
- Protein Kinases -- metabolism
- Signal Transduction -- drug effects
- Sirtuin 1 -- metabolism
- Sleep Apnea, Obstructive -- complications
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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