Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling. [electronic resource]
Producer: 20190626Description: 12618 p. digitalISSN:- 2045-2322
- Animals
- Brain -- physiopathology
- CRISPR-Cas Systems -- genetics
- Disease Models, Animal
- Epilepsy -- genetics
- Fibroblasts -- pathology
- GTPase-Activating Proteins -- genetics
- Gene Expression Regulation
- Heterozygote
- Humans
- Mechanistic Target of Rapamycin Complex 1 -- genetics
- Mice
- Mice, Knockout
- Multiprotein Complexes -- chemistry
- Mutation
- Seizures -- genetics
- Signal Transduction -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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