Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. [electronic resource]
Producer: 20180123Description: 732 p. digitalISSN:- 2041-1723
- Animals
- Antineoplastic Agents -- pharmacology
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Female
- Humans
- Leucine -- metabolism
- Leucine-tRNA Ligase -- genetics
- Mechanistic Target of Rapamycin Complex 1 -- genetics
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Monomeric GTP-Binding Proteins -- genetics
- Neoplasms -- enzymology
- Protein Binding -- drug effects
- Signal Transduction -- drug effects
- Sirolimus -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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