Tyrosines-740/751 of PDGFRβ contribute to the activation of Akt/Hif1α/TGFβ nexus to drive high glucose-induced glomerular mesangial cell hypertrophy. [electronic resource]
Producer: 20180718Description: 44-53 p. digitalISSN:- 1873-3913
- Cells, Cultured
- Gene Expression Regulation
- Glucose -- pharmacology
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- antagonists & inhibitors
- Mesangial Cells -- drug effects
- Mutation
- Phosphatidylinositol 3-Kinase -- genetics
- Phosphorylation -- drug effects
- Protein Biosynthesis
- Proto-Oncogene Proteins c-akt -- genetics
- RNA, Small Interfering -- genetics
- Receptor, Platelet-Derived Growth Factor beta -- antagonists & inhibitors
- Signal Transduction
- Transforming Growth Factor beta -- genetics
- Tyrosine -- metabolism
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Publication Type: Journal Article
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