The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer. [electronic resource]
Producer: 20180109Description: 36-48 p. digitalISSN:- 1096-9896
- Aged
- Biomarkers -- metabolism
- Colonic Neoplasms -- diagnosis
- DEAD Box Protein 58 -- genetics
- DNA-Binding Proteins
- Epigenomics
- Female
- Humans
- Immunity, Innate
- Inflammatory Bowel Diseases -- complications
- Interferon-Induced Helicase, IFIH1 -- genetics
- Male
- Nuclear Proteins -- genetics
- Prognosis
- RNA, Small Interfering
- Receptors, Immunologic
- Sequence Analysis, RNA
- Signal Transduction
- Transcription Factors -- genetics
- Tretinoin -- metabolism
- Tripartite Motif Proteins -- genetics
- Ubiquitin-Protein Ligases -- genetics
- Ubiquitination
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Publication Type: Journal Article
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