Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis. [electronic resource]
Producer: 20180226Description: 216-231 p. digitalISSN:- 1535-4989
- Animals
- Bleomycin
- Cell Hypoxia -- physiology
- Cell Line
- Dichloroacetic Acid -- pharmacology
- Glycolysis -- physiology
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- genetics
- Lung -- pathology
- Mice
- Mice, Knockout
- Myofibroblasts -- cytology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pulmonary Fibrosis -- chemically induced
- Pyruvate Dehydrogenase Acetyl-Transferring Kinase
- RNA Interference
- RNA, Small Interfering -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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