Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions. [electronic resource]
Producer: 20180629Description: 1304-1316 p. digitalISSN:- 1521-009X
- Cytochrome P-450 CYP2C19 -- metabolism
- Cytochrome P-450 CYP3A -- metabolism
- Cytochrome P-450 Enzyme Inhibitors -- pharmacology
- Drug Interactions
- Enzyme Induction -- drug effects
- Gastric Acidity Determination
- Histone Deacetylase Inhibitors -- adverse effects
- Humans
- Hydroxamic Acids -- adverse effects
- Indoles -- adverse effects
- Microsomes, Liver -- enzymology
- Midazolam -- pharmacokinetics
- Models, Biological
- Oxidation-Reduction
- Panobinostat
- Rifampin -- pharmacokinetics
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Publication Type: Journal Article
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