Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. [electronic resource]
Producer: 20180514Description: 319-331.e8 p. digitalISSN:- 1875-9777
- Astrocytes -- drug effects
- Autoimmune Diseases -- enzymology
- Base Sequence
- Cell Extracts
- Child
- Cytosol -- metabolism
- DNA -- metabolism
- Exodeoxyribonucleases -- deficiency
- Humans
- Infant
- Infant, Newborn
- Inflammation -- pathology
- Interferons -- pharmacology
- Long Interspersed Nucleotide Elements -- genetics
- Male
- Microcephaly -- pathology
- Nervous System -- pathology
- Neural Stem Cells -- metabolism
- Neurons -- drug effects
- Organoids -- metabolism
- Phenotype
- Phosphoproteins -- deficiency
- Stem Cells -- drug effects
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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