The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain. [electronic resource]
Producer: 20190109Description: 4792 p. digitalISSN:- 2045-2322
- Administration, Oral
- Animals
- Antineoplastic Agents -- pharmacology
- Bone Neoplasms -- complications
- Bone and Bones -- drug effects
- Cell Line, Tumor
- Dasatinib -- pharmacology
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Reporter
- Luciferases -- genetics
- Mammary Neoplasms, Animal -- complications
- Osteoclasts -- drug effects
- Osteosarcoma -- complications
- Pain -- drug therapy
- Pain Management -- methods
- Pain Measurement -- methods
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Rats
- Rats, Sprague-Dawley
- Receptors, N-Methyl-D-Aspartate -- genetics
- Signal Transduction
- Tartrate-Resistant Acid Phosphatase -- antagonists & inhibitors
- src-Family Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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