Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target. [electronic resource]
Producer: 20180220Description: 1986-1992 p. digitalISSN:- 1554-8937
- Animals
- Antineoplastic Agents -- chemistry
- Caco-2 Cells
- Cells, Cultured
- DNA Repair Enzymes -- antagonists & inhibitors
- Drug Delivery Systems
- Enzyme Activation -- drug effects
- HeLa Cells
- Hepatocytes -- drug effects
- Humans
- MCF-7 Cells
- Mice
- Mice, Nude
- Microsomes, Liver -- drug effects
- Models, Molecular
- Morpholines -- chemistry
- Neoplasms -- drug therapy
- Phosphoric Monoester Hydrolases -- antagonists & inhibitors
- Pyrimidines -- chemistry
- Rats
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Publication Type: Research Support, Non-U.S. Gov't; Journal Article
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