Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1. [electronic resource]
Producer: 20170811Description: 3923-3933 p. digitalISSN:- 1520-4995
- Amino Acid Substitution
- Arginine -- chemistry
- Binding, Competitive
- Biocatalysis
- Catalytic Domain
- Enzyme Inhibitors -- pharmacology
- Enzyme Stability
- Evolution, Molecular
- Humans
- Hydrogen Bonding
- Hydrolysis
- Ligands
- Lysine -- chemistry
- Models, Molecular
- Molecular Conformation
- Mutagenesis, Site-Directed
- Mutation
- Nitrophenols -- chemistry
- Organophosphonates -- chemistry
- Organophosphorus Compounds -- chemistry
- Organothiophosphorus Compounds -- chemistry
- Protein Phosphatase 1 -- antagonists & inhibitors
- Recombinant Proteins -- chemistry
- Substrate Specificity
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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